Kicking AIDS Out offers an innovative, inclusive, high energy approach that links sports, physical activity and traditional movement games with HIV and AIDS prevention and education. Kicking AIDS Out begun as an African initiative aimed at children and youth. Kicking AIDS Out has developed into an evolving international network of ‘southern’ and ‘northern’ partner- and member organisations and associates. Trained youth leaders who can engage their peers in sports, provide accurate health-related information and skillfully create safe spaces for discussion on many sensitive issues are essential factors in the initiative’s success.